Monowave 450

  • Monowave 400 with on-top automation, in an attractive package
  • Unattended processing of 24 vials of different sizes
  • Specially designed vessels for solvent extraction or bulky samples
  • Remote control via VNC
  • Environmental footprint reduction
  • 21 CFR Part 11-compliant

Microwave reactor: Monowave 450


The Anton Paar Monowave product line is a series of high-performance monomode microwave reactors designed for small- to medium-scale microwave synthesis.

Attain temperatures up to 300 °C and pressures up to 30 bar with advanced all-the-time safety features for high-speed, high-pressure, high-temperature reactions. Improve productivity and product purity across all applications in research and development laboratories with precise heating profiles. Reduce consumable costs and your environmental footprint by using the reusable vials, caps, and septa.

Visit our world of microwave synthesis to find your optimum reaction conditions and to browse through a database of more than 1000 applications which have been successfully performed in Anton Paar reactors.

Key features

Fast and effective: 24 sequential reactions, unattended

The Autosampler MAS 24 allows 24 unattended reactions, in sequence – saving time, and increasing efficiency. High field density produces fast, uniform heating for all kinds of reactions, up to 300 °C. Powerful stirring of up to 1200 rpm assures temperature homogeneity. The powerful 850 W magnetron adjusts its unpulsed microwave power automatically to the sample. This software-driven self-tuning eliminates any guesswork about sample absorption. Achieve high yields and clean reactions with maximum reproducibility.

The key factor in synthesis: Precise, scalable temperature measurement

Current scientific practice is to use reaction temperature as the relevant parameter in microwave reactions. And accurate measurement of the reaction temperature is the key to correct transferal and scale-up of reaction protocols between different reactors. Monowave reactors measure the temperature via an IR temperature sensor – a robust and reliable method for temperature control ensuring absolutely precise temperature measurement. For accurate control of even more demanding reactions, such as an exothermic reactions, or those involving extremely sensitive samples, simultaneous internal temperature measurement with the optional fiber-optic ruby thermometer is available.

Vials for heating any solvent and any reaction mixture

In addition to the standard glass vials, silicon carbide (SiC) vessels are available. They absorb microwave energy efficiently, while shielding the interior from microwave radiation – a method that reveals microwave effects caused by selective absorption, and allows comparison between direct microwave heating and conventional heating of reaction mixtures. All parameters, such as the heating and cooling rate, the form factor of the reaction vessel, and the stirring efficiency are identical, apart from the heating mode. All solvents, from non-absorbing ones such as hexane to excellent absorbers such as ionic liquids, can be heated to achieve equal performance – making Monowave the ideal instrument for solvent comparison across chemical reactions. Finally, even chemicals not suitable for glass vials (fluorination agents or alkaline samples) can be processed in the chemically inert, robust SiC vessels.

Save time, expenditure, and the environment with tool-free and reusable consumables

Choose from reaction vials for any scale between 0.5 mL and 20 mL. For bulky samples and extraction applications, a special wide-neck vessel offers convenience without compromising performance. Establish a hassle-free workflow in your laboratory with tool-free handling, and reduce the cost of ownership and the environmental footprint of your research by using reusable vials, septa, and caps.

See everything: Watch your synthesis and analyze it in real-time

With Monowave 400 and Monowave 450 you can record images and videos with the integrated digital camera. You can follow color changes and precipitation, check the dissolution of substrates, and optimize the stirring efficiency. Monowave 400 R can be combined with Anton Paar’s Cora 5001 Raman spectrometer for in-situ Raman spectroscopy measurements of chemical reactions. Identify intermediates and short-lived transition states, investigate reaction kinetics and optimize reaction conditions with real-time information about the chemical composition of your reaction. The contactless measurement removes any worries about cross-contamination and the need for cleaning in between experiments.

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